To improve performance, Sybase recommends that before you start the replication definition change process, disable sts_full_cache for rs_objects, rs_columns, and rs_functions, and then enable sts_full_cache for these tables after the replication definition change process. To disable sts_full_cache where system_table_name is the name of the table:
configure replication server set sts_full_cache_system_table_name to ‘off
See “Replication definition change request process,” in Chapter 9, “Managing Replicated Tables” in the Replication Server Administration Guide Volume 1.