Modify the default preferences for how the machine running SAP Sybase Event Stream Processor Studio connects with other ESP machines.
SAP Sybase Event Stream Processor Studio sets the Active Provider to Direct to guarantee that network connections do not use a proxy server. If your network requires a different setting (such as the Eclipse default of setting it to Native if present or Manual otherwise) you will have to modify the network preferences for SAP Sybase Event Stream Processor Studio.