Event 46 may indicate that:
A cache is so busy that the buffer at the end of the LRU chain is still processing. Query monDataCache and monCachePool to determine which cache is busy. Possible resolutions include: increasing the size of the cache, using sp_poolconfig to increase the wash size, and increasing the housekeeper activity by retuning enable housekeeper GC.
Disk writes are taking a long time to complete. Query monIOQueue and monDeviceIO to determine if there is a slow or overloaded disk device.