If a system procedure is executed in a database other than sybsystemprocs, it operates on the system tables in the database in which it was executed.
For example, if the database owner of pubs2 runs sp_adduser in pubs2, the new user is added to pubs2..sysusers.
Opening that database with the use command and execute the procedure, or
Qualifying the procedure name with the database name.
exec pubs2..sp_foo
------------------------------ pubs2 (1 row affected, return status = 0)
exec sybsystemprocs..sp_foo
------------------------------ sybsystemprocs (1 row affected, return status = 0)