A transaction that modifies primary data in more than one data server may require additional concurrency control. According to the transaction processing requirements, either all of the operations in the transaction are performed or none of them are performed. If a transaction fails on one data server, it must be rolled back on all other data servers updated in the transaction.
Normally, there is exactly one Replication Agent for each primary database. If a single transaction updates multiple primary databases, that transaction is replicated as multiple independent transactions, one for each primary database. Or, you can select to encapsulate such transactions in a single stored procedure, which then flows as an atomic unit to subscribing sites.