If you are making many changes to the RSSD, such as creating, altering, or dropping replication definitions, or customizing function strings, Sybase recommends that before you start the replication definition change process, disable sts_full_cache for rs_objects, rs_columns, and rs_objfunctions, and then set sts_full_cache for these tables to their original values after the replication definition change process.
configure replication server set sts_full_cache_system_table_name to ‘off
See Replication Server Administration Guide Volume 1 > Manage Replicated Tables > Modify Replication Definitions > Alter Replication Definitions > Replication Definition Change Request Process.