Before creating and modifying routes, you need to:
Make sure the source Replication Server is running.
If you are creating a direct route, define the destination Replication Server in the interfaces file at the site of the source Replication Server.
You should also have an interfaces file entry for the RSSD of the destination Replication Server.
Make sure that the RepAgent thread for the source Replication Server RSSD is running.
Make sure that the destination Replication Server and any intermediate Replication Servers in the route are running.