You can manage a database from within PowerBuilder.
For the most part, the Database painter works the same in PowerBuilder .NET as in PowerBuilder Classic.
PowerBuilder 12.5 provides enhanced support for connecting to any .NET provider through a managed ADO.NET interface. You can use the built-in ADO.NET drivers for Oracle, Adaptive Server Enterpriseā¢, and SQL Server from PowerBuilder Classic or PowerBuilder .NET applications. These drivers enable you to access most of the current database features of those providers.
See New Features in PowerBuilder 12 in the online help.