Some PowerBuilder features require the use of the PB.INI file, but many features use the registry for getting and storing configuration information. Normally, you should not need to access or modify items in the registry directly.
Information related to your preferences (such as the applications you have created, the way you have arranged your views in the painters, and the shortcut keys you have defined for PowerBuilder menu items) is stored in HKEY_CURRENT_USER/Software/Sybase/PowerBuilder/12.5.
Installation-related information is stored in HKEY_LOCAL_MACHINE/Software/Sybase/PowerBuilder/12.5.