Full control permissions are required for directories containing databases that you need to access from your Web Forms applications.
Before a PowerBuilder .NET Web Forms application connects to a SQL Anywhere® database, you must either start the database manually or grant the ASPNET user (IIS 5 on Windows XP), the IIS_WPG user group, or IIS_IUSRS (IIS 7 on Windows Vista and IIS 7.5 on Windows 7) default permissions for the Sybase\Shared and Sybase SQL Anywhere directories, making sure to replace permissions of all child objects in those directories.
If you do not grant the appropriate user permissions for Sybase directories and your database configuration is set to start the database automatically, your application will fail to connect to the database. SQL Anywhere cannot access files unless the ASPNET, IIS_WPG, or IIS_IUSRS user group has the right to access them.