You can install Replication Server 15.0.1 in an existing Sybase installation directory if that directory contains Adaptive Server version 15.0 or Open Client/Server™ version 15.0.
Do not install Replication Server 15.0.1 in an existing Sybase installation directory if that directory contains these Sybase products:
Replication Server version 12.5 or earlier
Adaptive Server version 12.5.0.x or earlier
Open Client/Server version 12.5.0 or earlier
OpenSwitch version 12.5 or earlier
DirectConnect™ version 12.5 or earlier
WARNING! Installing Replication Server 15.0.1 on top of any of these products incapacitates older versions of these products, and can also adversely affect other Sybase products.
You cannot reverse this with an uninstallation.