Replication Server offers a simplified process for upgrading user databases and RSSDs.
With Replication Server 15.6, you can use sysadmin upgrade, "route" to upgrade routes seamlessly instead of the Replication Manager plug-in to Sybase Central™.
With Replication Server 15.7.1, you can use an upgrade process that is simplified further to automatically upgrade the embedded Replication Server System Database (ERSSD) or Replication Server System Database (RSSD). Replication Server also connects to each user database that it has maintenance user access to and automatically applies the upgrade scripts to the database.
See Replication Server Configuration Guide > Upgrade or Downgrade Replication Server > Upgrading Replication Server > Upgrading RSSD or ERSSD with repserver.