Check this list for possible Replication Agent configuration errors:
If any parameter is set to insert a null in a replicate column, make sure the column allows nulls in all the replicate tables.
The Replication Agent configuration file is case sensitive, so make sure the case of all parameter values in the file is consistent.
Make sure that any Replication Agent configuration parameters listed as optional have a value entered, are commented out, or are deleted. Leaving a parameter name without a value in an uncommented state can cause a syntax error.
If the value of the retry configuration parameter is too low, your CPU usage can be unnecessarily high during network outages. This is because the host retries the connection every n seconds, where n is the value specified in the retry configuration parameter. If the value is too high, delays in processing can occur following network outages. Valid values range from 1 (one second) to 86400 (one day).
See Appendix A, “LTM for MVS Configuration Parameters,” for more information on the retry configuration parameter.